English | 威尼斯商人在线观看高清 | 校历
研究方向
林一瀚课题组的研究聚焦在单细胞水平上定量解析人类发育、疾病及免疫等重要过程中的基因调控机制,并利用合成生物器件对这些过程实施精准干扰或控制。研究从以下几个方面展开:在单细胞水平上动态解析肿瘤及免疫细胞的状态异质性、表观机制对基因表达和细胞群体异质性的影响、转录因子动力学在信号传导及基因调控中的功能和设计原理、数据驱动的基因调控网络推断及构建,及新型合成生物学器件的设计和应用。
实验室致力于开展前沿的生命科学交叉研究,有机结合了包括系统生物学、合成生物学、定量单细胞分析、活细胞时序荧光成像、数学建模等研究方法。同时,为了引领单细胞研究领域,实验室正在研发高通量、高时空分辨率的单细胞分析工具,用于解析疾病过程中的基因调控网络,并为单细胞水平上药物筛选及大规模测试合成生物学器件等应用提供新平台。
代表性科研论文
At PKU:
1.Jiegen Wu, Baoqiang Chen, Yadi Liu, Liang Ma, Wen Huang, Yihan Lin*. Modulating gene regulation function by chemically controlled transcription factor clustering. Nature Communications 2022, 13, Article number:2663 (*corresponding author).
2. Yan Wu, Jiaqi Wu, Minghua Deng, Yihan Lin*. Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs. Nature Communications 2021, 12(1), 1-13 (*corresponding author).
3. Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*. Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells. Molecular Systems Biology 2020, 16, e9335 (*corresponding author).
4. Jianhan Zhang#, Xu Han#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology 2018, 16(12): e3000095 (*corresponding author).
5. Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B. Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems 2018, 7(4): 453-462.
6. Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, …, Michael B. Elowitz*, Molecular time sharing through dynamic pulsing in single cells, Cell Systems 2018, 6(2): 216-229.
7. Liang Ma, Zeyue Gao, Jiegen Wu, Bijunyao Zhong, Yuchen Xie, Wen Huang, Yihan Lin*. Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics. Molecular Cell 2021, 81, 1-16 (*corresponding author).
Prior to PKU:
7. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai & Michael B. Elowitz*. Combinatorial gene regulation by modulation of relative pulse timing, Nature 2015, 527(7576):54-58
8. Joseph H. Levine#, Yihan Lin#, & Michael B. Elowitz*. Functional roles of pulsing in genetic circuits. Science, 342(6163): 1193-1200, 2013 (# co-first author)
9. Yihan Lin and Michael B. Elowitz*, Central dogma goes digital, Molecular Cell, 61: 791-792, 2016.
10. Yihan Lin, Ying Li, Sean Crosson, Aaron R. Dinner* & Norbert F. Scherer*, Phase resetting reveals network dynamics underlying a bacterial cell cycle, PLOS Computational Biology, 8(11): e1002778, 2012
11.Yihan Lin, Sean Crosson* & Norbert F. Scherer*, Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion, Molecular Systems Biology, 6: 445, 2010.